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Open AccessArticle10.18705/1607-419x-2013-19-5-435-441

HYPERHOMOCYSTEINEMIA AS A FACTOR OF FIBRINOLYSIS DISTURBANCES IN PATIENTS WITH ACTIVATED INTRAVASCULAR COAGULATION

Т. Ф. Субботина,A. F. Zhloba-2013-10-28-Arterial’naya Gipertenziya (Arterial Hypertension)
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TL;DRAbstract

Background. High blood concentration of D-dimer is a reliable marker of activation of intravascular coagulation, but does not provide unambiguous information about the functional potential of the ibrinolytic system. Objective. To determine the contribution of hyperhomocysteinemia (HHcy) in ibrinolysis disturbances in patients with activated intravascular coagulation. Design and methods. Plasma samples of 141 patients with activated intravascular coagulation of various etiologies [82 women (58,2 %) and 59 men (41,8 %), mean age 53,2 ± 7,8 years] with the level of D-dimer > 500 ng/ml were studied. The level of total Hcy (tHcy) was determined by high-performance liquid chromatography. In 57 samples ibrinolytic capacity was investigated by turbidimetric global coagulation and ibrinolysis test using as inducers thrombin and tissue plasminogen activator, respectively. 20 samples of donors matched for age and sex served as a comparison group. Results. In 52 patients (36,9 % of the total sa

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Background. High blood concentration of D-dimer is a reliable marker of activation of intravascular coagulation, but does not provide unambiguous information about the functional potential of the ibrinolytic system. Objective. To determine the contribution of hyperhomocysteinemia (HHcy) in ibrinolysis disturbances in patients with activated intravascular coagulation. Design and methods. Plasma samples of 141 patients with activated intravascular coagulation of various etiologies [82 women (58,2 %) and 59 men (41,8 %), mean age 53,2 ± 7,8 years] with the level of D-dimer > 500 ng/ml were studied. The level of total Hcy (tHcy) was determined by high-performance liquid chromatography. In 57 samples ibrinolytic capacity was investigated by turbidimetric global coagulation and ibrinolysis test using as inducers thrombin and tissue plasminogen activator, respectively. 20 samples of donors matched for age and sex served as a comparison group. Results. In 52 patients (36,9 % of the total sa

Keywords

HyperhomocysteinemiaFibrinolysisDisseminated intravascular coagulationCoagulationMedicineInternal medicineD-dimerGastroenterology

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