Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective

TL;DRAbstract

Background: studying and apprehending the pathways and mechanisms by which overweight and obesity trigger complex disease progression is of prime importance for the development of therapy and prevention measures of this major public health burden. This review describes Single Nucleotide Polymorphisms (SNPs) and epigenetic methylation as well as histone modification in genes with relevance in adaptive thermogenesis and their possible role in the development of obesity. Epigenetic marks are discussed as solid biomarkers for gene-environment interactions. Methods: a PubMed search on genetic and epigenetic variation of genes involved in adaptive thermogenesis was performed. The search included English publications between December 1996 and July 2010 reporting associations between SNPs and obesity in Caucasians. The search on epigenetic regulation was limited to DNA methylation and histone modifications. Genes that were found to be associated with the adaptive thermogenesis pathway included

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