Studio Multidisciplinare sulle complicanze neurologiche in bambini affetti da Anemia Falciforme Valutazione con metodiche Ultrasonografiche, Neuroradiologiche, test Neuropsicologici e Neurofisiologici

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ABSTRACT Sickle cell disease (SCD) is a genetic disorder caused by abnormal haemoglobin that damages and deforms red blood cells. Sickle cell anemia (SCA) is the most severe form of SCD developing when two sickle genes are inherited (homozygotic HbSS) . Sickle cell disease is in the world, the most common genetic disease. Each year more than 300,000 children are born with SCD, mainly in Africa, India and Albania (data WHO 2008). The SCA is an increasing global health problem (Weatherall DJ 2001) . Neurologic complications are frequent among the most serious and disabling. Stroke is a frequent complication of SCD. Approximately 11% of children have a clinical stroke before 20 years of age (Ohene-Frempong K. 1998) and another 35% have a silent infarcts on magnetic resonance imaging (Pegelow C. 2002) with serious sequelae psycho-cognitive and learning difficulties (Schatz J 2002). Screening programs for stroke prevention in SCD children have been implemented using Transcranial Doppler (TC

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