Are Uremia, Diabetes, and Atherosclerosis Linked with Impaired Antioxidant Mechanisms?

doi:https://doi.org/10.2310/jim.0b013e3181641ce3

Are Uremia, Diabetes, and Atherosclerosis Linked with Impaired Antioxidant Mechanisms?

Belda Dursun,Evrim Dursun,Irfan Capraz,Tomris Özben,Ali Apaydın,Gültekin Süleymanlar-2008-02-01-Journal of Investigative Medicine

24

TL;DRAbstract

Increased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM.

Chat with Paper

AI Agents for this Paper

Increased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM.

Keywords

Oxidative stressInternal medicineDiabetes mellitusMedicineUremiaIntima-media thicknessEndocrinologyMalondialdehyde

Chat

Click to start Chat