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Open AccessArticle10.21320/2500-2139-2013-6-1-46-52

New markers (CD160, CD200, and LAIR-1) in diagnosis of B-cell lymphoproliferative disorders

С А Луговская,Д Г Кисиличина,М Е Почтарь,Е. В. Наумова,Eugene Nikitin,L. S. Al-Radi-2013-01-01-Clinical oncohematology
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Flow cytometry is used in diagnosis and classification of B-cell lymphoproliferative disorders, measuring expression level of target antigen and monitoring of minimal residual disease. Immunological phenotype of tumor B cells is not always in accord with classical characteristic and it makes complicated the interpretation of data, and therefore there is a need to find additional informative markers. Using new monoclonal antibodies to CD160, CD200 and LAIR-1 enhances the diagnostic capabilities of flow cytometry.

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Flow cytometry is used in diagnosis and classification of B-cell lymphoproliferative disorders, measuring expression level of target antigen and monitoring of minimal residual disease. Immunological phenotype of tumor B cells is not always in accord with classical characteristic and it makes complicated the interpretation of data, and therefore there is a need to find additional informative markers. Using new monoclonal antibodies to CD160, CD200 and LAIR-1 enhances the diagnostic capabilities of flow cytometry.

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