Abstract 8635: Novel Role of the Osteoclast-Associated Receptor (oscar) In Oxidative Stress-Mediated Atherogenesis

TL;DRAbstract

Cross talk between the vascular and the immune system plays a crucial role in cardiovascular diseases including atherosclerosis and ectopic calcification. The osteoclast-associated receptor (OSCAR) is a regulator of osteoclast differentiation and dendritic cell maturation, and recently was implicated as a modulator of osteoimmunology. But the role of OSCAR in vascular biology and its impact on atherogenic processes provoked by pro-inflammatory stimuli is unknown. We recently identified OSCAR on the surface of human primary endothelial cells. Endothelial cell survival was significantly enhanced by activation of OSCAR (+22 %, p<0.001). In contrast, apoptosis was inhibited, as measured by DNA fragmentation (−19 %, p<0.01) and by determination of caspase 3/7 activity (−22 %, p<0.05). Furthermore, OSCAR overexpression increased adhesion of monocytic cells to the endothelium up to 2-fold (p<0.05). In an in-depth proteomic study using stable isotope labelling with amino acids in c

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