Facile One-Pot Two-Step Hydroxylation of Alkyl Halides and Alkyl Sulfonates via Acetate Intermediates

TL;DRAbstract

Hydroxylation of primary and secondary alkyl halides and alkyl sulfonates was readily achieved by one-pot two-step reaction under mild condition.Less reactive chloride and secondary mesylate functionalities were also transformed to hydroxide group in high yields.When 5% water-containing DMSO solvent was used, catalytic cycle of two-step hydroxylation smoothly proceeded in the presence of catalytic amount of acetate anion.

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