Chronic Glucose Infusion Increases Tubular Sodium Reabsorption and Renal Blood Flow in Dogs

TL;DRAbstract

It is not known whether hyperinsulinemia and/or hyperglycemia in metabolic syndrome contribute to the associated hypertension through chronic antinatriuretic actions. We tested this using chronic iv. glucose infusion to increase plasma insulin and glucose concentrations comparable to those measured in metabolic syndrome, and used 24 hr/day methods for measuring mean arterial pressure (MAP; DSI) and renal blood flow (RBF; Transonic). Blood glucose increased ~ 10 mg/dl over the 6‐day glucose infusion period, and plasma insulin increased from 28±4 to 45±12 µU/ml. Urinary sodium excretion averaged 70±8 mEq/d during control, decreased to 49±5 mEq/d on day 1 of glucose, and averaged 51±6 mEq/d over the 6 days. RBF averaged 123±17 ml/min during control, increased to 137±19 on day 1, and averaged 153±17 by day 6 of glucose. Plasma renin activity increased 3‐fold, and all variables returned to control values during recovery. MAP did not increase significantly. However, there was no tendency for

Chat with Paper

AI Agents for this Paper