Anti-ro/ssa, anti-la/ssb autoantibodies and antiphospholipid antibodies in serum of et/et mutant mice that show exocrinopathy

TL;DRAbstract

IN THIS PAPER, THE ANTI-RO/SSA, ANTI-LA/SSB AND ANTI-PHOSPHOLIPID ANTIBODIES' TITERS IN SERUM OF NUDE MUTANT MICE OF ET/ET, ET/ (HETEROZYGOUS) AND STRAINS, WERE COMPARATIVELY STUDIED, AND TITERS WERE CORRELATED WITH THE SEVERITY OF MAXILLARY AND LACRIMAL GLANDS' LESIONS. RESULTS SHOWED THAT GROSS OCULAR LESIONS WERE ASSOCIATED TO THE MUTANT STRAIN ET/ET. IN THIS STRAIN THE GLANDULAR WEIGHT HAD A NEGATIVE CORRELATION WITH THE AGE (R = -0.370, P = 0.011), THE PRESENCE OF ANTI-RO/SSA AND ANTI-LA/SSB AUTOANTIBODIES SHOWED 13.5% AND 10.5% OF POSITIVITY, RESPECTIVELY, AND BOTH ANTIBODIES WERE ASSOCIATED TO THE ET/ET STRAIN, ONLY 1/5 OF THE SERA GAVE POSITIVE TO BOTH AUTOANTIBODIES. THE ANOVA TEST OF ANTIPHOSPHOLIPID ANTIBODY'S TITERS BETWEEN THE STRAINS SHOWED INCREASED TITERS OF IGM AND IGG ANTIBODIES IN THE ET/ET STRAIN, COMPARED TO THE AND ET/ STRAINS (P = 0.00 AND P = 0.004, RESPECTIVELY). THE WEIGHT OF THE LACRIMAL GLANDS SHOWED A NEGATIVE CORRELATION WITH THE PRESENCE OF ANTI RO/SSA AN

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