Alteration of biochemical profiles after high‐dose intravenous immunoglobulin administration in Kawasaki disease

TL;DRAbstract

Intravenous immunoglobulin (IVIG) has been used as an immunomodulatory treatment for several immune‐mediated diseases. Early effects of high‐dose IVIG treatment on biochemical profiles including lipids and proteins were evaluated in patients with Kawasaki disease (KD). Twelve children with KD (9 boys) were treated with IVIG at 2 g/kg over a period of 12 h. Serial sera samples were collected from the patients four times: before IVIG treatment and 2 h, 24 h and 7 d after IVIG treatment. The samples were frozen at –20°C before biochemical analysis. A significant decrease in albumin concentration was found 2 h and 24 h after IVIG treatment, but this recovered to the pretreatment level after 7 d. Total cholesterol and triglyceride increased slightly after 7 d. A significant decrease in HDL‐cholesterol and C‐reactive protein was seen 2 h and 24 h after IVIG treatment. Conclusion : High‐dose IVIG affects immediate changes in protein profiles and HDL‐cholesterol in KD. Changes in HDL‐cholester

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