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Article10.1161/circ.124.suppl_21.a17396

Abstract 17396: Iron Deficiency as the Most Ominous Substrate for Anemia in Patients Undergoing Coronary Artery Bypass Surgery

Susanne Weißert,Julia Flint,Suneil Aggarwal,Alistair Connell,Francesco Papalia,Girish Babu+4 more-2011-11-22-Circulation
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TL;DRAbstract

Background: Whilst pre-operative anemia escalates morbidity and mortality after coronary artery bypass grafting (CABG), it is unclear whether its different etiologies confer different magnitudes of risk. Because iron is quantitatively the most important biocatalyst in human physiology, we hypothesized that iron deficiency (ID) anemia (IDA) might confer the greatest hazard. Additionally, we supposed that ID even in the absence of anemia might be detrimental. Methods: We analysed hospital outcomes in 1910 CABG patients (mean [±SD] age 67±10 years, EuroSCORE 4±3%, 79% male, 36% CCS class>2). The combination of a red cell distribution width≥15% and a mean cell volume ≤80fL was utilised to identify ID as it has a ≥90% sensitivity and specificity for this diagnosis. A hemoglobin <13g/dL in males and <12g/dl in females defined anemia. Results: On admission, 70%, 27%, and 3% of patients had no anemia, non-iron deficiency anemia (NIDA), and IDA, respectively. Patients with IDA were mor

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Background: Whilst pre-operative anemia escalates morbidity and mortality after coronary artery bypass grafting (CABG), it is unclear whether its different etiologies confer different magnitudes of risk. Because iron is quantitatively the most important biocatalyst in human physiology, we hypothesized that iron deficiency (ID) anemia (IDA) might confer the greatest hazard. Additionally, we supposed that ID even in the absence of anemia might be detrimental. Methods: We analysed hospital outcomes in 1910 CABG patients (mean [±SD] age 67±10 years, EuroSCORE 4±3%, 79% male, 36% CCS class>2). The combination of a red cell distribution width≥15% and a mean cell volume ≤80fL was utilised to identify ID as it has a ≥90% sensitivity and specificity for this diagnosis. A hemoglobin <13g/dL in males and <12g/dl in females defined anemia. Results: On admission, 70%, 27%, and 3% of patients had no anemia, non-iron deficiency anemia (NIDA), and IDA, respectively. Patients with IDA were mor

Keywords

MedicineCoronary artery bypass surgeryAnemiaBypass surgeryArteryBypass graftingCoronary artery diseaseCardiology

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