Effect of fructose‐feeding on intestinal and renal expression of genes involved in fatty acid synthesis

TL;DRAbstract

Fructose is a potent stimulator of liver lipogenesis but little is known about the regulation of small intestinal (SI) genes involved in fatty acid synthesis, even though the SI contributes 10–40% of total body triglycerides. We pair‐fed two groups of 16 d old rats high fructose or glucose (control) solutions for 16 consecutive d (16F or 16G), and another two groups for 8 d followed by 8 d without sugars (8F or 8G) to evaluate the long‐term effects of fructose on the regulation of fatty acid metabolism. The expression of the fructose transporter GLUT5 was high in the liver, SI and kidney but only in the SI did fructose markedly upregulate GLUT5. In the liver but not in the SI of 16F fed rats, expression of lipogenic enzymes (FAS, HmGCoA, and Malic Enzyme 1) and the triglyceride transfer protein MTP were much greater than that in 16G, 8F and 8G. In the SI, withdrawal of sugar feeding in 16F and 16G markedly inhibited the expression of Malic Enzymes 1 and 3, MTP and HmGCoA in comparison

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