Mechanism of Garlic Protection Against Coronary Endothelial Dysfunction and Right Ventricular Hypertrophy (RVH) in Pulmonary Hypertensive (PH) Rats: Comparisons among Fresh, Boiled and Aged Garlics

TL;DRAbstract

We recently found that coronary endothelial (EC) dysfunction associated and preceded the development of MCT-induced PH and RVH. Preliminary data showed a protective effect of garlic against this EC dysfunction and RVH. To investigate the possible mechanism for garlic effect, we pretreated the rats with either 1% fresh garlic powder (GQ), boiled GQ (BGQ) or aged garlic (Kyolic-KYO) prior to MCT injection. Mass spectrometric (LC/MS with ESI) analyses of GQ extracts showed a distinct allicin (163 M+H+) peak. Only allicin precursor, alliin, was found after heart inactivation of allicin synthesis in BGQ (Figure 1). KYO does not contain allicin either. Significant PH (34±4 mmHg) and RVH (40±2% of septum+LV weight) were found 3 weeks after MCT injection (vs. 19±2 mmHg and 25±1% of S+LV in controls, respectively). GQ treatment prevented PH (20±2 mmHg) and RVH (27±1% of S+LV), but BGQ (30±2 mmHg and 46±3% of S+LV) and KYO (28±2 mmHg and 47±5% of S+LV) treatments did not. In isolated right coron

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