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Article10.1161/circ.128.suppl_22.a216

Abstract 216: The Cerebral Blood Flow Threshold for Membrane Repolarization is 3 Times Higher Than That for Membrane Depolarization and is Lowered by Intraischemic Hypothermia

Ryoichi Mizoue,Yoshimasa Takeda,Sachiko Sato,Ken Takata,Hiroshi Morimatsu-2013-11-26-Circulation
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TL;DRAbstract

Introduction: It has been reported that cerebral blood flow (CBF) supplied by chest compression (20-40% of control levels) exceeds the CBF threshold for membrane depolarization (20%). However, the CBF threshold for membrane repolarization has not been studied. It is unknown whether chest compression can restore membrane potential. In the present study, we compared the CBF threshold for depolarization with that for repolarization. In addition, the effects of brain hypothermia on the repolarization threshold were evaluated. Methods: Rats (10 in each group) were anesthetized with isoflurane. CBF was measured by placing a laser-Doppler flow probe placed adjacent to a direct current (DC) potential electrode in the parietal cerebral cortex. Following bilateral occlusion of common carotid artery, CBF was continuously decreased by exsanguination at a speed of 5% of the baseline level every 2 min until a sudden negative DC shift was observed. After 5 or 10 min of ischemic depolarization, the CB

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Introduction: It has been reported that cerebral blood flow (CBF) supplied by chest compression (20-40% of control levels) exceeds the CBF threshold for membrane depolarization (20%). However, the CBF threshold for membrane repolarization has not been studied. It is unknown whether chest compression can restore membrane potential. In the present study, we compared the CBF threshold for depolarization with that for repolarization. In addition, the effects of brain hypothermia on the repolarization threshold were evaluated. Methods: Rats (10 in each group) were anesthetized with isoflurane. CBF was measured by placing a laser-Doppler flow probe placed adjacent to a direct current (DC) potential electrode in the parietal cerebral cortex. Following bilateral occlusion of common carotid artery, CBF was continuously decreased by exsanguination at a speed of 5% of the baseline level every 2 min until a sudden negative DC shift was observed. After 5 or 10 min of ischemic depolarization, the CB

Keywords

MedicineDepolarizationHypothermiaCerebral blood flowRepolarizationBlood flowAnesthesiaCardiology

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