ATP plays a role as a danger signal that activates macrophages during adenoviral infection (133.38)

TL;DRAbstract

Abstract We have previously shown that adenovirus infection of epithelial cells and macrophages co-culture resulted in synergistic induction of pro-inflammatory mediators such as cytokines, nitric oxide (NO), and reactive oxygen species (ROS) and caused cytotoxic responses. Here, we investigated whether ATP plays a role during the inflammatory response against adenovirus using the co-culture system. We found that pre-treatment of the co-culture with oxidized-ATP inhibited induction of NO and ROS and reduced cytotoxicity during adenoviral infection. Furthermore, we demonstrated that ATP signalling through P2X7 receptor is required in generation of NO and ROS using P2X7 deficient macrophage cell line. These results indicate that ATP plays a role as a danger signal to regulate macrophage activation during inflammatory response against adenoviral infection.

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